COVID-19: Brief overview of therapeutic strategiesReview Published on 2023-02-012023-07-11 Journal: Anaesthesia, critical care & pain medicine [Category] COVID19(2023년), [키워드] antiviral therapies COVID-19 oxygen. [DOI] 10.1016/j.accpm.2022.101181 PMC 바로가기 [Article Type] Review
Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promiseReview article Published on 2022-11-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] SARS, 바이오마커, 변종, 치료제, [키워드] addition anti-inflammatory property Antiviral antiviral action antiviral therapies changes Complication COVID-19 COVID-19 pandemic current Cytokine storm death direct infection endothelial damage Endothelium Evidence function host cell Hydrogen sulfide Hyperinflammatory Infection Inflammation iNOS limit nitric oxide occur platform Protective pulmonary damage rationale reduce Respiratory failure Respiratory system resulting SARS-CoV-2 signaling molecule supportive therapy therapeutic approaches thrombosis Treatment Vascular vasculature viral infection viral infections [DOI] 10.1016/j.niox.2022.08.003 [Article Type] Review article
Essential Services: Quantifying the Contributions of America’s Pharmacists in COVID-19 Clinical InterventionsResearch article Published on 2022-08-012022-10-05 Journal: Journal of the American Pharmacists Association : [Category] 변종, 임상, 진단, 치료제, [키워드] accounted Administered antibodies antibody Antiviral medications antiviral therapies association Care clinical Community conducted contributed convalescent plasma COVID-19 COVID-19 pandemic COVID-19 tests COVID-19 vaccination deaths Diagnosis diagnostic tests Essential estimates Government Health healthcare help hospitalizations Immunization Neighborhood Infectious disease Influenza Intervention mitigate monoclonal antibodies National objective pandemic Patient Pharmacist Pharmacy provided public health Result review SARS-CoV-2 Spread Support supportive therapies The United States Treatment vaccination Vaccinations Vaccines [DOI] 10.1016/j.japh.2022.08.010 [Article Type] Research article
The global succinylation of SARS-CoV-2-infected host cells reveals drug targetsSARS-CoV-2에 감염된 숙주 세포의 세계적인 숙시닐화는 약물 표적을 드러낸다Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral drug target antiviral effects antiviral therapies Caco-2 Caco-2 cells causative agent cellular cellular pathway cellular pathways conserved COVID-19 COVID-19 pandemic demonstrated drug target enzyme Evolution highlighting Host host cell host protein inhibit inhibitor Interaction mechanism membrane protein Membrane proteins metabolic pathways Modification nsp14 overexpressed promote Protein Quantitative regulated Regulatory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SIRT5 sirtuin succinylproteomics. variants Viral proteins virus replication [DOI] 10.1073/pnas.2123065119 PMC 바로가기 [Article Type] Article
Modeling transmission of SARS-CoV-2 Omicron in China중국 SARS-CoV-2 Omicron 전파 모델링Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Accessibility adopted antiviral therapies antiviral therapy calibrated China Clinical endpoints Coverage COVID-19 Critical care deaths debate Disruption Efficacy Epidemic Factor growth Growth phase Healthcare system Hospitalization hypothetical Immunity implementation individual initial intensive care modeling nonpharmaceutical intervention Nonpharmaceutical interventions omicron outbreak Patient Prevent respond SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 variants Shanghai Transmissibility transmission of SARS-CoV-2 vaccination Vaccine vaccine efficacy [DOI] 10.1038/s41591-022-01855-7 PMC 바로가기 [Article Type] Article
The 2022 outbreak and the pathobiology of the monkeypox virusArticle Published on 2022-07-012022-11-15 Journal: Journal of autoimmunity [Category] 진단, [키워드] addition African Antiviral antiviral therapies body fluids CDC center chills clade clades Congo basin Control disease effective Europe fatigue Fever headache Host hosts identity include individual Infection Infectious disease International lymph nodes mitigate Monkeypox Monkeypox outbreak 2022 muscle aches nasopharyngeal National Nigeria North America outbreak pandemic Pathogenesis Prevalence Prevent prevention raised replicate reported Respiratory droplets returned rodent shown specific treatment Spread Symptom The United States through contact Transmission transmitted Travel USA Vaccine Viral pathogenesis. virus virus infection virus spread Washington West while WHO World Health Organization [DOI] 10.1016/j.jaut.2022.102855 PMC 바로가기
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance약물 내성을 예측하고 피하기 위한 SARS-CoV-2 주요 프로테아제의 기질 외피 정의Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral therapies antiviral therapy antivirals binding cleavage Clinical use COVID-19 pandemic Critical drug resistance effective Efficacy elements enzyme Enzymes High-resolution identify inhibitor inhibitors M pro maturation morbidity and mortality Mutation nine peptide peptides polymerases predict promote protease Protease inhibitor protease inhibitors Proteases resistance mutations robust SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variant SARS-CoV-2 variants severe disease Spread Structure susceptible to define treatment strategy Vaccine viral pathogen [DOI] 10.1038/s41467-022-31210-w PMC 바로가기 [Article Type] Article
Development of Metal Complexes for Treatment of Coronaviruses코로나바이러스 치료를 위한 금속 착체 개발Article Published on 2022-06-082022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] advent analyzed antibody antiviral therapies binding affinity Complete complex complexes Complexes contradiction coronavirus coronavirus disease coronavirus variants country COVID-19 Critical death described determine development disease docking effective Epidemic Infection lockdown mechanism metal metal complexes New coronavirus pandemic PDB pharmacokinetics pharmacophore pharmacophore. Prevent promise protease Protein Protein Data Bank RCSB pdb (Protein Data Bank) database related disease required Research SARS-CoV-2 Spread Structure structures suggested Toxicity transfer Treatment Vaccine variants virus [DOI] 10.3390/ijms23126418 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 main protease doesn’t induce cell death in human cells in vitroSARS-CoV-2 주요 프로테아제는 시험관 내에서 인간 세포에서 세포 사멸을 유도하지 않습니다Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antiviral therapies Apoptosis Cell cell death cell line cell lines contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication COVID-19 Cytopathic effect cytotoxicity detect develop effective enzyme expression homologous human cell human cell lines in vitro inactivated induce molecular mechanism molecular mechanisms morphology multifunctional Pathogenesis protease Protein proteolytic activity required SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread the SARS-CoV-2 therapeutic target unlikely variant viability viral infection [DOI] 10.1371/journal.pone.0266015 PMC 바로가기 [Article Type] Article
Global mapping of RNA homodimers in living cells살아있는 세포에서 RNA 동종이량체의 전역 매핑Article Published on 2022-05-012022-09-11 Journal: Genome research [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] antiviral therapies assembly chimeric conserved data sets detect disrupt domain effective genomes homodimer human transcriptome in vitro in vivo infected cells involved lack living cell N gene Paris physiological Region reveal RNA SARS-CoV-2 sequence snoRNA snRNA subcellular localization subset target Transcriptome transcriptome-wide transcripts tRNAs viral genome viral genomes virus-infected cell virus-infected cells zebrafish Zika [DOI] 10.1101/gr.275900.121 PMC 바로가기 [Article Type] Article